[HTML][HTML] Current development of the second generation of mTOR inhibitors as anticancer agents
HY Zhou, SL Huang - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, acts as a
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …
Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment
BH Jiang, LZ Liu - Drug resistance updates, 2008 - Elsevier
The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …
protein synthesis, ribosomal protein translation, and cap-dependent translation …
[HTML][HTML] Defining the role of mTOR in cancer
DA Guertin, DM Sabatini - Cancer cell, 2007 - cell.com
The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-
signaling pathways commonly deregulated in human cancers. This has led to the prediction …
signaling pathways commonly deregulated in human cancers. This has led to the prediction …
Mammalian target of rapamycin as a therapeutic target in oncology
RT Abraham, CH Eng - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: The mammalian target of rapamycin (mTOR) has emerged as a validated
therapeutic target in cancer and mTOR inhibitors alter tumor cell responses to mitogenic …
therapeutic target in cancer and mTOR inhibitors alter tumor cell responses to mitogenic …
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
T Sato, A Nakashima, L Guo, K Coffman, F Tamanoi - Oncogene, 2010 - nature.com
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety
of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells …
of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells …
mTOR and cancer: many loops in one pathway
A Efeyan, DM Sabatini - Current opinion in cell biology, 2010 - Elsevier
The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division
that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last …
that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last …
[HTML][HTML] mTOR inhibitors in cancer therapy
The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation,
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …
[HTML][HTML] mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
SY Sun - Frontiers of Medicine, 2021 - Springer
The mammalian target of rapamycin (mTOR) critically regulates several essential biological
functions, such as cell growth, metabolism, survival, and immune response by forming two …
functions, such as cell growth, metabolism, survival, and immune response by forming two …
Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …
required for several biological activities involving cell proliferation. The serine-threonine …
Dissecting the role of mTOR: lessons from mTOR inhibitors
RJO Dowling, I Topisirovic, BD Fonseca… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Recent years have observed significant advances in our understanding of how the
serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as …
serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as …