[HTML][HTML] Current development of the second generation of mTOR inhibitors as anticancer agents

HY Zhou, SL Huang - Chinese journal of cancer, 2012 - ncbi.nlm.nih.gov
The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase, acts as a
“master switch” for cellular anabolic and catabolic processes, regulating the rate of cell …

Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment

BH Jiang, LZ Liu - Drug resistance updates, 2008 - Elsevier
The mammalian target of rapamycin (mTOR) pathway plays a central role in regulating
protein synthesis, ribosomal protein translation, and cap-dependent translation …

[HTML][HTML] Defining the role of mTOR in cancer

DA Guertin, DM Sabatini - Cancer cell, 2007 - cell.com
The mammalian target of rapamycin (mTOR) has emerged as a critical effector in cell-
signaling pathways commonly deregulated in human cancers. This has led to the prediction …

Mammalian target of rapamycin as a therapeutic target in oncology

RT Abraham, CH Eng - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: The mammalian target of rapamycin (mTOR) has emerged as a validated
therapeutic target in cancer and mTOR inhibitors alter tumor cell responses to mitogenic …

Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

T Sato, A Nakashima, L Guo, K Coffman, F Tamanoi - Oncogene, 2010 - nature.com
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates a variety
of cellular functions such as growth, proliferation and autophagy. In a variety of cancer cells …

mTOR and cancer: many loops in one pathway

A Efeyan, DM Sabatini - Current opinion in cell biology, 2010 - Elsevier
The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division
that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last …

[HTML][HTML] mTOR inhibitors in cancer therapy

J Xie, X Wang, CG Proud - F1000Research, 2016 - ncbi.nlm.nih.gov
The mammalian target of rapamycin, mTOR, plays key roles in cell growth and proliferation,
acting at the catalytic subunit of two protein kinase complexes: mTOR complexes 1 and 2 …

[HTML][HTML] mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

SY Sun - Frontiers of Medicine, 2021 - Springer
The mammalian target of rapamycin (mTOR) critically regulates several essential biological
functions, such as cell growth, metabolism, survival, and immune response by forming two …

Role of mammalian target of rapamycin (mTOR) signalling in oncogenesis

M El-Tanani, H Nsairat, AA Aljabali, Á Serrano-Aroca… - Life Sciences, 2023 - Elsevier
The signalling system known as mammalian target of rapamycin (mTOR) is believed to be
required for several biological activities involving cell proliferation. The serine-threonine …

Dissecting the role of mTOR: lessons from mTOR inhibitors

RJO Dowling, I Topisirovic, BD Fonseca… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Recent years have observed significant advances in our understanding of how the
serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as …