The mTOR pathway: a new target in cancer therapy

L Ciuffreda, C Di Sanza, UC Incani… - Current cancer drug …, 2010 - ingentaconnect.com
Mammalian target of rapamycin (mTOR) is a key protein kinase controlling signal
transduction from various growth factors and upstream proteins to the level of mRNA …

Targeting mTOR globally in cancer: thinking beyond rapamycin

B Shor, JJ Gibbons, RT Abraham, K Yu - Cell cycle, 2009 - Taylor & Francis
The mammalian target of rapamycin (mTOR) is centrally involved in growth, survival and
metabolism. In cancer, mTOR is frequently hyperactivated and is a clinically validated target …

Akt-dependent and-independent mechanisms of mTOR regulation in cancer

RM Memmott, PA Dennis - Cellular signalling, 2009 - Elsevier
The protein kinase mTOR (mammalian target of rapamycin) is a critical regulator of cellular
metabolism, growth, and proliferation. These processes contribute to tumor formation, and …

Targeting mTOR for cancer therapy

H Hua, Q Kong, H Zhang, J Wang, T Luo… - Journal of hematology & …, 2019 - Springer
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …

mTOR: a cellular regulator interface in health and disease

F Boutouja, CM Stiehm, HW Platta - Cells, 2019 - mdpi.com
The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine
kinase, which has a central function in integrating growth signals and orchestrating their …

The enigma of rapamycin dosage

S Mukhopadhyay, MA Frias, A Chatterjee… - Molecular cancer …, 2016 - AACR
The mTOR pathway is a critical regulator of cell growth, proliferation, metabolism, and
survival. Dysregulation of mTOR signaling has been observed in most cancers and, thus, the …

Role of mTOR signaling in tumor cell motility, invasion and metastasis

H Zhou, S Huang - Current Protein and Peptide Science, 2011 - ingentaconnect.com
Tumor cell migration and invasion play fundamental roles in cancer metastasis. The
mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed …

[HTML][HTML] mTOR function and therapeutic targeting in breast cancer

SH Hare, AJ Harvey - American journal of cancer research, 2017 - ncbi.nlm.nih.gov
The mTOR pathway was discovered in the late 1970s after the compound and natural
inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus …

Key factors in mTOR regulation

X Bai, Y Jiang - Cellular and molecular life sciences, 2010 - Springer
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a
wide range of growth-related cellular processes. In the past several years, many factors …

mTOR signaling, function, novel inhibitors, and therapeutic targets

R Watanabe, L Wei, J Huang - Journal of nuclear medicine, 2011 - Soc Nuclear Med
Mammalian target of rapamycin (mTOR) is an evolutionally conserved serine/threonine
kinase that integrates signals from multiple pathways, including nutrients (eg, amino acids …