The movement toward precision medicine with targeted therapeutics for cancer treatment
has been hindered by both innate and acquired resistance. Understanding the molecular …

Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that belongs to
Phosphatidylinositol-3-kinase related kinase superfamily. The signaling pathways of mTOR …

Mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that
regulates cell cycle progression, protein translation, metabolism, and cellular proliferation …

Mammalian target of rapamycin (mTOR) is an atypical protein kinase that controls growth
and metabolism in response to nutrients, growth factors and cellular energy levels, and it is …

The immunosuppressive drug rapamycin played a key role in the functional characterization
of mammalian target of rapamycin (mTOR), an unusual protein kinase that coordinates …

mTOR (mechanistic target of rapamycin) functions as the central regulator for cell
proliferation, growth and survival. Up-regulation of proteins regulating mTOR, as well as its …

The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation,
metabolism and angiogenesis. mTOR signaling is often dysregulated in various human …

A puzzling aspect of rapamycin-based therapeutic strategies is the wide disparity in the
doses needed to suppress mTOR under different circumstances. A recent study revealing …

Small molecule inhibitors that selectively target cancer cells and not normal cells would be
valuable anti-cancer therapeutics. The mammalian target of rapamycin complex 2 …