Research progress of mTOR inhibitors
Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …
Therapeutic targeting of the mTOR‐signalling pathway in cancer: benefits and limitations
M Moschetta, A Reale, C Marasco… - British journal of …, 2014 - Wiley Online Library
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of
protein translation, cell growth and metabolism. The mTOR protein forms two distinct multi …
protein translation, cell growth and metabolism. The mTOR protein forms two distinct multi …
Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
S Chan - British journal of cancer, 2004 - nature.com
Abstract mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a
critical role in regulating basic cellular functions. These include cell proliferation, survival …
critical role in regulating basic cellular functions. These include cell proliferation, survival …
mTORC1 and mTORC2 in cancer and the tumor microenvironment
The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates
environmental cues to regulate cell survival, proliferation and metabolism, and is often …
environmental cues to regulate cell survival, proliferation and metabolism, and is often …
[HTML][HTML] mTOR signaling in growth control and disease
M Laplante, DM Sabatini - cell, 2012 - cell.com
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …
The complexes of mammalian target of rapamycin
H Zhou, S Huang - Current protein and peptide science, 2010 - ingentaconnect.com
The mammalian target of rapamycin (mTOR) has attracted substantial attention because of
its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and …
its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and …
Targeting mTOR for cancer treatment
B Rubio-Viqueira, M Hidalgo - New trends in cancer for the 21st century, 2006 - Springer
The mammalian target of rapamycin (mTOR) is involved in the control of cellular growth and
proliferation. Abnormal activation of signaling pathways both proximal and distal to this …
proliferation. Abnormal activation of signaling pathways both proximal and distal to this …
mTOR signaling
M Laplante, DM Sabatini - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
mTOR Signaling Page 1 mTOR Signaling Mathieu Laplante and David M. Sabatini Centre
de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ) …
de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ) …
The role of mTOR signaling as a therapeutic target in cancer
NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …