Research progress of mTOR inhibitors

Y Chen, X Zhou - European journal of medicinal chemistry, 2020 - Elsevier
Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr)
protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein …

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

V Panwar, A Singh, M Bhatt, RK Tonk… - Signal transduction and …, 2023 - nature.com
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular
metabolism, catabolism, immune responses, autophagy, survival, proliferation, and …

Therapeutic targeting of the mTOR‐signalling pathway in cancer: benefits and limitations

M Moschetta, A Reale, C Marasco… - British journal of …, 2014 - Wiley Online Library
The mammalian target of rapamycin (mTOR) plays an important role in the regulation of
protein translation, cell growth and metabolism. The mTOR protein forms two distinct multi …

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer

S Chan - British journal of cancer, 2004 - nature.com
Abstract mTOR is a downstream mediator in the PI3K/Akt signalling pathway, which plays a
critical role in regulating basic cellular functions. These include cell proliferation, survival …

mTORC1 and mTORC2 in cancer and the tumor microenvironment

LC Kim, RS Cook, J Chen - Oncogene, 2017 - nature.com
The mammalian target of rapamycin (mTOR) is a crucial signaling node that integrates
environmental cues to regulate cell survival, proliferation and metabolism, and is often …

[HTML][HTML] mTOR signaling in growth control and disease

M Laplante, DM Sabatini - cell, 2012 - cell.com
The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a
variety of environmental cues to regulate organismal growth and homeostasis. The pathway …

The complexes of mammalian target of rapamycin

H Zhou, S Huang - Current protein and peptide science, 2010 - ingentaconnect.com
The mammalian target of rapamycin (mTOR) has attracted substantial attention because of
its involvement in a variety of diseases, such as cancer, cardiac hypertrophy, diabetes and …

Targeting mTOR for cancer treatment

B Rubio-Viqueira, M Hidalgo - New trends in cancer for the 21st century, 2006 - Springer
The mammalian target of rapamycin (mTOR) is involved in the control of cellular growth and
proliferation. Abnormal activation of signaling pathways both proximal and distal to this …

mTOR signaling

M Laplante, DM Sabatini - Cold Spring Harbor …, 2012 - cshperspectives.cshlp.org
mTOR Signaling Page 1 mTOR Signaling Mathieu Laplante and David M. Sabatini Centre
de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec (CRIUCPQ) …

The role of mTOR signaling as a therapeutic target in cancer

NV Popova, M Jücker - International Journal of Molecular Sciences, 2021 - mdpi.com
The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …