The use of cytokines from the IL-2 family (also called the common γ chain cytokine family)
such as interleukin (IL)-2, IL-7, IL-15, and IL-21 to activate the immune system of cancer …

Simple Summary Emerging knowledge of the two type I cytokine family members IL-2 and IL-
15 has led to critical therapeutic implications for cancer treatment. Here we discuss the …

Most studies focus on the first and second signals of T cell activation. However, the roles of
cytokines in immunotherapy are not fully understood, and cytokines have not been widely …

Abstract Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death
of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in …

Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function
and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell …

Interleukin‐21 (IL‐21) is the newest member of the common γ‐chain family of cytokines,
which includes IL‐2, IL‐4, IL‐7, IL‐9, IL‐13, and IL‐15. Its private receptor, IL‐21R, has been …

The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …

Interleukin-21 is the most recently discovered member of the type-I cytokine family.
Structurally, IL-21 shows homology to IL-2, IL-4, and IL-15 proteins. IL-21 shares the …

Abstract Interleukin-21 (IL-21) is a cytokine with structural and sequence homology to IL-2
and IL-15, yet possesses several biological properties distinct from these cytokines. IL-21 is …

Abstract The interleukin-1 (IL-1) family is one of the first described cytokine families and
consists of eight cytokines (IL-1β, IL-1α, IL-18, IL-33, IL-36α, IL-36β, IL-36γ and IL-37) and …