Research progress on the utilisation of embedding technology and suitable delivery systems for improving the bioavailability of nattokinase: a review

X Zhou, L Liu, X Zeng - Food Structure, 2021 - Elsevier
Nattokinase is a thrombolytic drug that is more advantageous than urokinase, streptokinase,
and tissue plasminogen activator because of its low price, high efficiency, and nontoxic side …

Chitosan/casein based microparticles with a bilayer shell–core structure for oral delivery of nattokinase

X Zhang, X Lyu, Y Tong, J Wang, J Ye, R Yang - Food & function, 2020 - pubs.rsc.org
Nattokinase is a thrombolytic enzyme obtained from Japanese traditional food natto for
prevention and cure of thrombosis-related cardiovascular diseases. However, the …

Improvement of the stability of nattokinase using γ-polyglutamic acid as a coating material for microencapsulation

CW Hsieh, WC Lu, WC Hsieh, YP Huang… - LWT-Food Science and …, 2009 - Elsevier
In this study, nattokinase (NK) was microencapsulated in high-molecular-weight Na-γ-PGA,
and the amount of NK added to the Na-γ-PGA was in the ratio of 1: 1 and 2: 1 w/w, which …

Microencapsulation of nattokinase from fermentation by spray drying: Optimization, comprehensive score, and stability

G Li, T Li, F He, C Chen, X Xu, W Tian… - Food Science & …, 2021 - Wiley Online Library
Nattokinase from fermentation has recently gained more attention due to its beneficial effects
on cardiovascular system. However, the instability of free nattokinase limits its application …

Stabilization and target delivery of nattokinase using compression coating

D Law, Z Zhang - Drug development and industrial pharmacy, 2007 - Taylor & Francis
The aim of the work is to develop a new formulation in order to stabilize a nutraceutical
enzyme Nattokinase (NKCP) in powders and to control its release rate when it passes …

Protective effect of ovalbumin-flavonoid hydrogel on thrombolytic activity and stability of nattokinase

Y Zhong, L Yang, Z Zhu, H Chen, C Liu, T Dai… - Food Research …, 2022 - Elsevier
The protective effect of ovalbumin-flavonoids (naringenin, genistein, naringin, puerarin, and
daidzein) hydrogels on the thrombolytic activity and stability of nattokinase were …

Expression of nattokinase in Escherichia coli and renaturation of its inclusion body

H Ni, PC Guo, WL Jiang, XM Fan, XY Luo, HH Li - Journal of Biotechnology, 2016 - Elsevier
Nattokinase is an important fibrinolytic enzyme with therapeutic applications for
cardiovascular diseases. The full-length and mature nattokinase genes were cloned from …

Strain screening, fermentation, separation, and encapsulation for production of nattokinase functional food

X Wei, M Luo, Y Xie, L Yang, H Li, L Xu… - Applied biochemistry and …, 2012 - Springer
This study presents a novel and integrated preparation technology for nattokinase functional
food, including strain screening, fermentation, separation, and encapsulation. To rapidly …

Downstream processing, formulation development and antithrombotic evaluation of microbial nattokinase

R Kapoor, H Harde, S Jain, AK Panda… - Journal of Biomedical …, 2015 - ingentaconnect.com
The present research work describes the downstreaming of nattokinase (NK) produced by
Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of …

Extracellular production of a potent and chemically resistant nattokinase in immobilized Escherichia coli using response surface methodology

F Mohammadi, N Nezafat, A Berenjian… - Current …, 2018 - ingentaconnect.com
Background: Nattokinase is a potent fibrinolytic protease, which is used as a drug for
treatment or a supplement for preventing thrombosis besides various industrial applications …