Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …

Acute lymphoblastic leukemia (ALL) cells disrupt the healthy bone marrow
microenvironment to create a leukemic niche that is crucial for facilitating leukemogenesis …

Highlights•Hematopoietic progenitors are interconnected by F-actin-dependent TNTs.•Cell
dislodgement is the primary mechanism responsible for TNT biogenesis.•TNTs emerge from …

Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular
communication in the leukemic bone marrow participates in disease development …

Tunneling nanotubes (TNT) are dynamic connections between cells, which represent a
novel route for cell-to-cell communication. A growing body of evidence points TNT towards a …

The interaction between tumor cells and macrophages is crucial in promoting tumor invasion
and metastasis. In this study, we examined a novel mechanism of intercellular …

Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …

Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …

We investigated and modeled the mesenchymal stromal cell (MSC) niche in adult acute
lymphoblastic leukemia (ALL). We used gene expression profiling, cytokine/chemokine …

The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic
leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the …