Given the inherent therapeutic potential of the morphogenetic plasticity of adult human islets,
the identification of factors controlling their cellular differentiation is of interest. The …

The upregulation of a limited number of growth factors in our interferon-γ transgenic model
for regeneration within the pancreas lead us to propose that these factors are important …

During embryonic life, the development of a proper mass of mature pancreatic tissue is
thought to require the proliferation of precursor cells, followed by their differentiation into …

Pancreatic acini and islets are believed to differentiate from common ductal precursors
through a process requiring various growth factors. Epidermal growth factor receptor (EGF …

Pancreatic duct cells are considered to be a major source for β‐cell regeneration or
neogenesis. Although epidermal growth factor (EGF) is a well‐known important growth …

Tissue plasticity is well documented in the context of pancreatic regeneration and
carcinogenesis, with recent reports implicating dedifferentiated islet cells both as endocrine …

Background & Aims: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is
expressed in both normal pancreatic islets and in pancreatic cancers, but its role in …

Activated signaling proteins regulate diverse processes, including the differentiation of the
pancreatic islet cells during ontogeny. Here we uncover the in vivo phosphorylation status of …

Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth factor
receptors). Even partial tissue-specific attenuation of EGFR signalling in the islets leads to …

The neuregulin (NRG)/epidermal growth factor (EGF) family of growth factors consists of
several ligands that specifically activate four erbB receptor-tyrosine kinases, namely erbB-1 …