We have used an insulin-like growth factor (IGF)-II transgenic mouse model in which mouse
IGF-II is widely overexpressed, resulting in increased fetal size and selective organ …

OBJECTIVE The generation of mature cell types during pancreatic development depends on
the expression of many regulatory and signaling proteins. In this study, we tested the …

BACKGROUND & AIMS: Epidermal growth factor (EGF), transforming growth factor alpha
(TGF-alpha), and the EGF receptor are often overexpressed in chronic pancreatitis and in …

The endocrine pancreas is an organ of enormous importance, since its dysfunction causes
diabetes, one of the most common human diseases in the world. Regulation of pancreatic …

The polypeptide mitogen, epidermal growth factor (EGF), was originally isolated from mouse
submaxillary gland (SMG). In mice, these glands are sexually dimorphic; the SMG of male …

EPIDERMAL growth factor (EGF) secretion and EGF receptor (EGFR) expression were
studied by a combination of reverse hemolytic plaque assay (RHPA), which identifies the …

Epidermal growth factor (EGF) acts on various cell types, including the mouse Leydig tumor
cell line MA-10, where it has been shown to stimulate steroidogenesis, apparently in a cAMP …

The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-
IR) in the apoptosis/survival of Leydig cells. Immunohistochemical analysis of the rat testis at …

The pancreas is characterized by a major component, an exocrine and ductal system
involved in digestion, and a minor component, the endocrine islets represented by islet …

Epidermal growth factor (EGF) is one of growth factors that are thought to mediate the
stimulatory effects of estrogen on the proliferation of uterine epithelial cells. The present …