The interaction of protein S with the phospholipid surface is essential for the activated protein C-independent activity of protein S
M van Wijnen, JG Stam, C van't Veer… - Thrombosis and …, 1996 - thieme-connect.com
Protein S is a vitamin-K dependent glycoprotein involved in the regulation of the
anticoagulant activity of activated protein C (APC). Recent data showed a direct …
anticoagulant activity of activated protein C (APC). Recent data showed a direct …
Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity
KM Seré, MP Janssen, GM Willems, G Tans… - Biochemistry, 2001 - ACS Publications
Protein S, the cofactor of activated protein C (APC), also expresses anticoagulant activity
independent of APC by directly inhibiting prothrombin activation via interactions with factor …
independent of APC by directly inhibiting prothrombin activation via interactions with factor …
The anticoagulant properties of a modified form of protein S
CA Mitchell, SM Kelemen… - Thrombosis and …, 1988 - thieme-connect.com
Protein S (PS) is a vitamin K-dependent anticoagulant that acts as a cofactor to activated
protein C (APC). To date PS has not been shown to possess anticoagulant activity in the …
protein C (APC). To date PS has not been shown to possess anticoagulant activity in the …
[HTML][HTML] Human protein S inhibits prothrombinase complex activity on endothelial cells and platelets via direct interactions with factors Va and Xa.
TM Hackeng, C Van't Veer, JC Meijers… - Journal of Biological …, 1994 - Elsevier
Protein S is a vitamin K-dependent non-enzymatic coagulation factor involved in the
regulation of activated protein C (APC). In this paper we report an APC-independent …
regulation of activated protein C (APC). In this paper we report an APC-independent …
A plasma coagulation assay for an activated protein C-independent anticoagulant activity of protein S
M van Wijnen, C van't Veer, JCM Meijers… - Thrombosis and …, 1998 - thieme-connect.com
To study the physiological importance of the activated protein C (APC)-independent
anticoagulant activity of protein S, we developed an assay specific for this activity. The ability …
anticoagulant activity of protein S, we developed an assay specific for this activity. The ability …
Activated Protein C-Dependent and–Independent Anticoagulant Activities of Protein S Have Different Structural Requirements
MJ Heeb, JH Griffin - Blood Cells, Molecules, and Diseases, 2002 - Elsevier
Plasma protein S exhibits multiple anticoagulant activities. About 20% of protein S normally
circulates in a form that is cleaved in its thrombin-sensitive region (TSR, residues 47–72) …
circulates in a form that is cleaved in its thrombin-sensitive region (TSR, residues 47–72) …
Amino acid residues in thrombin-sensitive region and first epidermal growth factor domain of vitamin K-dependent protein S determining specificity of the activated …
X He, L Shen, BO Villoutreix, B Dahlbäck - Journal of Biological Chemistry, 1998 - ASBMB
Human protein S (PS) potentiates the anticoagulant activity of human but not bovine
activated protein C (APC), whereas bovine PS is a cofactor to APC from both species. The …
activated protein C (APC), whereas bovine PS is a cofactor to APC from both species. The …
Protein S as cofactor for TFPI
TM Hackeng, J Rosing - Arteriosclerosis, thrombosis, and vascular …, 2009 - Am Heart Assoc
In the last decades evidence was obtained that protein S not only acts as cofactor of
activated protein C (APC) in the downregulation of coagulation, but also expresses …
activated protein C (APC) in the downregulation of coagulation, but also expresses …
[HTML][HTML] Protein S multimers and monomers each have direct anticoagulant activity
MJ Heeb, P Schuck, X Xu - Journal of Thrombosis and Haemostasis, 2006 - Elsevier
Summary Background and Objectives: Plasma protein S (PS) is an essential anticoagulant
that has activated protein C‐independent, direct anticoagulant activity (PS‐direct). It was …
that has activated protein C‐independent, direct anticoagulant activity (PS‐direct). It was …
Inhibition of the intrinsic factor X activating complex by protein S: evidence for a specific binding of protein S to factor VIII
SJ Koppelman, TM Hackeng, JJ Sixma, BN Bouma - 1995 - ashpublications.org
Protein S is a vitamin K-dependent nonenzymatic anticoagulant protein that acts as a
cofactor to activated protein C. Recently it was shown that protein S inhibits the …
cofactor to activated protein C. Recently it was shown that protein S inhibits the …