Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs) are thought to be the major cause of failure in cancer therapy due to their …

In recent years, in situ chemotherapy mediated by biodegradable polymer platforms has
attracted increased attention. Herein, an advanced drug delivery system, combretastatin A-4 …

Localized cancer treatments with combination drugs have recently emerged as crucial
approaches for effective inhibition of tumor growth and reoccurrence. In this study, we …

Osteosarcoma is the most common malignancy in the bone. Current chemotherapy offers
limited efficacy with significant side effects, especially for advanced and relapsed …

Purpose Osteosarcoma is considered as the most common primary malignant bone tumor in
children and adolescents, and the treatments including chemotherapy and surgery were far …

Osteosarcoma is the most common primary malignant bone tumor in the pediatric age
group, and chemotherapy directed by targeted nanoparticulate drug delivery system …

Osteosarcoma is one of the most serious bone malignancies with rapid speed of
deterioration and low survival rate in children and teenagers. Chemotherapy is an important …

Osteosarcoma (OSA) is a difficult cancer to treat due to its tendency for relapse and
metastasis; advanced methods are therefore required for OSA treatment. In this study, we …

Background Chemotherapy resistance of osteosarcoma (OS) is still the crux of poor clinical
curative effect. E3 ubiquitin-protein ligase Rad18 (Rad18) contributed to doxorubicin …

Osteosarcoma is among the most common malignant bone tumors in human skeletal
system. The conventional treatment of osteosarcoma mainly consists of combining …