CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests
that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB …

Although CD95L (also known as FasL) is still predominantly considered as a death ligand
that induces apoptosis in infected and transformed cells, substantial evidence indicate that it …

Endothelial cells lining new blood vessels that develop during inflammatory disorders or
cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent …

Apoptosis is a fundamental process that contributes to tissue homeostasis, immune
responses, and development. The receptor CD95, also called Fas, is a member of the tumor …

Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …

Since the ligand for the death factor CD95 (CD95L) was identified almost a decade ago, it
has been established that this molecule (CD95L, FasL, Apo-1L, CD178, TNFSF6, APT1LG1) …

Although the interaction of CD95L (also known as FasL) with its so-called death receptor
CD95 (Fas) induces an apoptotic signal responsible for the elimination of infected and …

Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune
response, and during development. CD95 (also known as Fas), a member of the tumor …

The role of CD95 (Fas/Apo1) in cancer has been a matter of debate for over 30 years. First
discovered as an apoptosis-inducing molecule, CD95 soon emerged as a potential …

Patients affected by chronic inflammatory disorders display high amounts of soluble CD95L.
This homotrimeric ligand arises from the cleavage by metalloproteases of its membrane …