c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
C Tong, Z Yin, Z Song, A Dockendorff, C Huang… - The American journal of …, 2007 - Elsevier
The c-Jun NH2-terminal kinase (JNK) signal transduction pathway plays important roles in
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
cellular processes and stress. However, the role of JNK1 in intestinal homeostasis and …
c-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice
W Shibata, S Maeda, Y Hikiba, A Yanai, K Sakamoto… - Cancer research, 2008 - AACR
Abstract c-Jun NH2-terminal kinase (JNK) links several cellular processes, including
proliferation and survival, and is believed to be involved in carcinogenesis. However, the …
proliferation and survival, and is believed to be involved in carcinogenesis. However, the …
The role of JNK in the development of hepatocellular carcinoma
M Das, DS Garlick, DL Greiner… - Genes & …, 2011 - genesdev.cshlp.org
The cJun NH2-terminal kinase (JNK) signal transduction pathway has been implicated in the
growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that …
growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that …
Targets of c-Jun NH2-terminal Kinase 2-mediated Tumor Growth Regulation Revealed by Serial Analysis of Gene Expression
Although the c-Jun NH2-terminal kinase (JNK) pathway has been implicated in mediating
cell growth and transformation, its downstream effectors remain to be identified. Using JNK2 …
cell growth and transformation, its downstream effectors remain to be identified. Using JNK2 …
The c-Jun NH2-Terminal Kinase 2 Plays a Dominant Role in Human Epidermal Neoplasia
H Ke, R Harris, JL Coloff, JY Jin, B Leshin… - Cancer research, 2010 - AACR
The c-Jun NH2-terminal kinase (JNK) signaling cascade has been implicated in a wide
range of diseases, including cancer. It is unclear how different JNK proteins contribute to …
range of diseases, including cancer. It is unclear how different JNK proteins contribute to …
JNK2: a negative regulator of cellular proliferation
K Sabapathy, EF Wagner - Cell Cycle, 2004 - Taylor & Francis
The three different c-Jun N-terminal kinases (JNKs) are activated in multiple cell typesby
both apoptotic and mitogenic signals, and in turn regulate the activity of transcriptionfactors …
both apoptotic and mitogenic signals, and in turn regulate the activity of transcriptionfactors …
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
R Sancho, AS Nateri, AG De Vinuesa, C Aguilera… - The EMBO …, 2009 - embopress.org
Wnt signalling is a crucial signalling pathway controlling intestinal homeostasis and cancer.
We show here that the JNK MAP kinase pathway and one of its most important substrates …
We show here that the JNK MAP kinase pathway and one of its most important substrates …
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
L Hui, K Zatloukal, H Scheuch… - The Journal of …, 2008 - Am Soc Clin Investig
JNK proteins have been shown to be involved in liver carcinogenesis in mice, but the extent
of their involvement in the development of human liver cancers is unknown. Here, we show …
of their involvement in the development of human liver cancers is unknown. Here, we show …
A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches
c-Jun-N-terminal kinase (JNK) is a mitogen-activated protein kinase family member that is
activated by diverse stimuli, including cytokines (such as tumor necrosis factor and …
activated by diverse stimuli, including cytokines (such as tumor necrosis factor and …
Differential Gene Expression Profiles of Jnk1- and Jnk2-deficient Murine Fibroblast Cells
Abstract c-Jun NH2-terminal kinase (JNK) 1 and JNK2 have been assumed to complement
each other and mediate the same or similar biological functions. However, our recent reports …
each other and mediate the same or similar biological functions. However, our recent reports …
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