The phosphatidylinositol 3 kinase (PI3K)‐Akt/PKB pathway protects neurons from apoptosis
caused by diverse stress stimuli. However, its protective role against the amyloid beta …

Overproduction and accumulation of amyloid-β (Aβ) have been proposed to be an initiating
factor of neuron loss in Alzheimer's disease (AD). AKT is a pivotal molecule in regulating …

The phosphatidylinositol-3-kinase (PI3-K) pathway has been suggested to play a pivotal role
in neuronal survival. Although PI3-K has been recently identified as a neuroprotectant, there …

Exposure of rat hippocampal neurons to the peptide amyloid β (Aβ)(25–35) as well as Aβ (1–
40) peptides enhances phosphorylation of tau to a paired helical filament (PHF)-state …

Protein kinase C (PKC) isoforms are increasingly recognized as playing important roles in
the regulation of neuronal plasticity and survival. Recent findings from studies of non …

The p3 peptide [amyloid β‐peptide (Aβ) 17–40/42], derived by α‐and γ‐secretase cleavage
of the amyloid precursor protein (APP), is a major constituent of diffuse plaques in …

This study aims to investigate the roles of the protein kinase A (PKA)‐and caspase‐
dependent pathways in amyloid β‐peptide 31–35 (Aβ [31–35])‐induced apoptosis, and the …

Amyloid β-peptide (Aβ) is implicated as the toxic agent in Alzheimer's disease and is the
major component of brain amyloid plaques. In vitro, Aβ causes cell death, but the molecular …

42 β-Amyloid (Aβ 1–42) peptide is a key molecule involved in the development of
Alzheimer's disease. Some of its effects are manifested at the neuronal morphological level …

Amyloid β protein (Aβ) is deposited characteristically in the brain of patients with Alzheimer's
disease. Effects of protein kinase inhibitors (H-89, H-7, KN-62) on Aβ-induced neuronal cell …