Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow

JP Pelletier, J Martel-Pelletier, JP Raynauld - Arthritis research & therapy, 2006 - Springer
Osteoarthritis (OA), the most common of all arthritic conditions, is a social and financial
burden to all nations. The most recent research has significantly advanced our …

Current advances in therapies for osteoarthritis

KC Kalunian - Current Opinion in Rheumatology, 2016 - journals.lww.com
Current advances in therapies for osteoarthritis : Current Opinion in Rheumatology Current
advances in therapies for osteoarthritis : Current Opinion in Rheumatology Log in or Register …

[PDF][PDF] Future directions for research and treatment of osteoarthritis

CJ Malemud, VM Goldberg - Front Biosci, 1999 - article.imrpress.com
[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …

Pathobiology of osteoarthritis: pathomechanisms and potential therapeutic targets

HI Roach, T Aigner, S Soder, J Haag… - Current Drug …, 2007 - ingentaconnect.com
Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western
world. It affects first and foremost the articular cartilages and leads to a molecular and …

[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis

S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

[HTML][HTML] Rationale for the use of structure-modifying drugs and agents in the treatment of osteoarthritis

JP Pelletier - Osteoarthritis and cartilage, 2004 - Elsevier
This paper summarizes our current stand on potential pathophysiological targets for
osteoarthritis (OA) therapies. Although OA is a complicated disease, involving the cartilage …

Biologic basis of osteoarthritis: state of the evidence

CJ Malemud - Current opinion in rheumatology, 2015 - journals.lww.com
Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate
and adaptive immune systems accompanied by inflammation exemplified by the elevated …

Current treatment options for osteoarthritis

W Hermann, S Lambova… - Current rheumatology …, 2018 - ingentaconnect.com
Osteoarthritis (OA) is the most common joint disease and a leading cause for impaired
function and disability with significant treatment costs and socio-economic burden. Despite …

Emerging targets in osteoarthritis therapy

MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

[HTML][HTML] An update on the pathophysiology of osteoarthritis

A Mobasheri, M Batt - Annals of physical and rehabilitation medicine, 2016 - Elsevier
Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …