[HTML][HTML] Strategies to DAMPen COVID-19-mediated lung and systemic inflammation and vascular injury

C Bime, NG Casanova, J Nikolich-Zugich, KS Knox… - Translational …, 2021 - Elsevier
ABSTRACT Approximately 15%-20% of patients infected with SARS-CoV-2 coronavirus
(COVID-19) progress beyond mild and self-limited disease to require supplemental oxygen …

Comparison of COVID-19 induced respiratory failure and typical ARDS: similarities and differences

S Lu, X Huang, R Liu, Y Lan, Y Lei, F Zeng… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a predominantly respiratory infectious disease
caused by novel coronavirus infection (SARS-CoV-2), respiratory failure is the main clinical …

COVID-19: inflammatory profile

Y Wang, S Perlman - Annual review of medicine, 2022 - annualreviews.org
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has resulted in a pandemic that has had widespread …

Dysregulation of the immune response in coronavirus disease 2019

L Mohamed Khosroshahi, N Rezaei - Cell Biology International, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can trigger a cytokine
storm in the pulmonary tissue by releasing various types of mediators, leading to acute …

The pathogenesis of coronavirus-19 disease

AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …

Overview of COVID-19 inflammatory pathogenesis from the therapeutic perspective

C Lee, WJ Choi - Archives of pharmacal research, 2021 - Springer
The novel beta coronavirus (SARS-CoV-2, designated as COVID-19) that is responsible for
severe acute respiratory syndrome has devastated the global economy and health care …

Heightened innate immune responses in the respiratory tract of COVID-19 patients

Z Zhou, L Ren, L Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - Cell host & …, 2020 - cell.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …

Pathological features of COVID-19-associated lung injury: a preliminary proteomics report based on clinical samples

L Leng, R Cao, J Ma, D Mou, Y Zhu, W Li, L Lv… - … and Targeted Therapy, 2020 - nature.com
The COVID-19 pandemic has emerged as a global health emergency due to its association
with severe pneumonia and relative high mortality. However, the molecular characteristics …

Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement

KR Stenmark, MG Frid… - Pulmonary …, 2021 - journals.sagepub.com
The outbreak of COVID-19 disease, caused by SARS-CoV-2 beta-coronovirus, urges a
focused search for the underlying mechanisms and treatment options. The lung is the major …

Pathophysiology of COVID-19: mechanisms underlying disease severity and progression

MK Bohn, A Hall, L Sepiashvili, B Jung… - …, 2020 - journals.physiology.org
The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide
spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and …