The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

Comorbidities and clinical complications associated with SARS-CoV-2 infection: an overview

A Gupta, H Marzook, F Ahmad - Clinical and experimental medicine, 2023 - Springer
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes major
challenges to the healthcare system. SARS-CoV-2 infection leads to millions of deaths …

Overview of the pathogenesis of COVID‑19

C Li, Q He, H Qian, J Liu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
At present, the pathogenesis of the novel coronavirus disease 2019 (COVID‑19) has not
been fully elucidated. Clinical and experimental findings from studies investigating COVID …

SARS‐CoV‐2‐mediated immune system activation and potential application in immunotherapy

Y Tan, F Tang - Medicinal research reviews, 2021 - Wiley Online Library
Although novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐mediated
pulmonary inflammation has recently attracted great attention, its pathology and …

Biological mechanisms of COVID-19 acute respiratory distress syndrome

MA Matthay, A Leligdowicz, KD Liu - American journal of respiratory …, 2020 - atsjournals.org
Acute respiratory distress syndrome (ARDS) from severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) viral pneumonia has been the most serious and lethal …

[HTML][HTML] Pulmonary pathology of ARDS in COVID-19: A pathological review for clinicians

SS Batah, AT Fabro - Respiratory medicine, 2021 - Elsevier
COVID-19 has quickly reached pandemic levels since it was first reported in December
2019. The virus responsible for the disease, named SARS-CoV-2, is enveloped positive …

Pathogenesis of COVID-19-induced ARDS: implications for an ageing population

MAT Acosta, BD Singer - European Respiratory Journal, 2020 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …

Novel therapeutic targets for SARS-CoV-2-induced acute lung injury: Targeting a potential IL-1β/neutrophil extracellular traps feedback loop

A Yaqinuddin, J Kashir - Medical hypotheses, 2020 - Elsevier
Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5–10% of
cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of …

[HTML][HTML] Extrapulmonary clinical manifestations in COVID-19 patients

A Sarkesh, AD Sorkhabi, E Sheykhsaran… - The American journal …, 2020 - ncbi.nlm.nih.gov
COVID-19 manifestations in symptomatic patients can be in the form of pneumonia, acute
respiratory syndrome, and multiple organ dysfunction as well. Renal complications …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …