Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic targets?

JM Sallenave, L Guillot - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-
2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial …

[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …

Deciphering SARS-CoV-2 virologic and immunologic features

G Lebeau, D Vagner, E Frumence, F Ah-Pine… - International journal of …, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 and its associated
pathology, COVID-19, have been of particular concerns these last months due to the …

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential …

A Jafarzadeh, P Chauhan, B Saha, S Jafarzadeh… - Life sciences, 2020 - Elsevier
Abstract The COVID-19-, SARS-and MERS-related coronaviruses share many genomic and
structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and …

Dysregulated immune responses in SARS-CoV-2-infected patients: a comprehensive overview

I Kudryavtsev, A Rubinstein, A Golovkin, O Kalinina… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in
humans more than two years ago and caused an unprecedented socio-economic burden on …

Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications

IP Trougakos, K Stamatelopoulos, E Terpos… - Journal of Biomedical …, 2021 - Springer
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …

Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

M Wu, Y Chen, H Xia, C Wang… - Proceedings of the …, 2020 - National Acad Sciences
Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has
resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations

M Parotto, M Gyöngyösi, K Howe, SN Myatra… - The Lancet …, 2023 - thelancet.com
Individuals with SARS-CoV-2 infection can develop symptoms that persist well beyond the
acute phase of COVID-19 or emerge after the acute phase, lasting for weeks or months after …