An empirically-based approach which permits the comparison of changes in plasma
clearance caused by pharmacokinetic drug-interactions is described. The analysis is based …

Few topics in clinical medicine have attracted more attention during the past decade than
undesirable interactions between pharmacotherapeutic agents administered concomitantly …

Psychotropic drugs are commonly employed in the management of patients who are
medically ill. At least 35% of psychiatric consultations include recommendations for …

A growing concern relative to the. problem of drug interactions developed within the
profession in the late 1960's. This concern was vocalized by a number of professionals; …

With the increasing prevalence of polypharmacy, it is more important than ever to consider
the possibility of drug–drug interactions. A drug–drug interaction occurs when the way in …

Various nutritional and environmental factors are known to alter the rates at which drugs are
absorbed, distributed, metabolized, and eliminated from the body. Some of these factors …

• THE SUBJECT OF^ DRUG INTERACTIONS HAS ELICITED widespread interest among
pharmacists in recent years. If pharmacists are to expand their knowledge and services as …

Publisher Summary The concurrent use of more than one drug can significantly alter the
therapeutic effect of each drug and the adverse reaction profile. The regulatory framework in …

Recognition of the need for improvement of drug-related health care prompted the
conscious promotion of the discipline of clinical pharmacology in many countries in Europe …

DRUG INTERACTIONS HAVE BEEN TERMED" a new profes sional responsibility... an
opportunity to increase his [the pharmacist's] usefulness as a member of the health team." …