In the last two decades several significant changes have been proposed in the receptor
theory that describes how ligands can interact with G protein‐coupled receptors (GPCRs) …

Inhaled selective β2-agonists are the most widely used treatment for obstructive airway
diseases. The classical mechanism of action of these drugs is considered as their ability to …

An endogenous defect in β 2-adrenoceptors that results in impaired relaxation of airway
smooth muscle was originally proposed as a putative underlying cause of the asthmatic …

β2-Adrenoceptor agonists evoke rapid bronchodilatation and are the mainstay of the
treatment of asthma symptoms worldwide. The mechanism of action of this class of …

Abstract β2-adrenoceptor agonists, often used in combination with corticosteroids, have
been extensively used for the treatment of asthma. However, concerns have been raised …

New long-acting beta 2-adrenoceptor agonists, formoterol and salmeterol, may soon appear
in several European countries for treatment of asthma. This review examines currently …

Asthma was originally thought to be associated with an intrinsic defect in β 2ADR (β 2-
adrenoceptor) function, tipping the balance towards parasympathetic bronchoconstriction …

Rational choice among β 2-AR agonists in acute and chronic asthma should be influenced
by differences in intrinsic efficacy among these agents. In acute severe asthma, a full agonist …

BACKGROUND AND PURPOSE Inhalation of a β‐adrenoceptor agonist (β‐agonist) is first‐
line asthma therapy, used for both prophylaxis against, and acute relief of …

Despite the passionate debate over the use of β2‐adrenoceptor agonists in the treatment of
airway disorders, these agents are still central in the symptomatic management of asthma …