Ceramide metabolism has emerged as a potential target for anticancer therapy. Here, the
potential usefulness of two novel synthetic ceramide analogs as anti-leukemic drugs was …

A variety of anti-cancer drugs elevate endogenous ceramide, thereby inducing apoptosis in
tumor cells. Recently, we have introduced novel ceramide analogs of the β-hydroxy alkyl …

Ceramide analogs are potential chemotherapeutic agents. We report that a ceramide analog
induces apoptosis in human prostate cancer cells. The ceramide analog induced cell death …

Multidrug-resistance is a major cause of cancer chemotherapy failure in clinical treatment.
Evidence shows that multidrug-resistant cancer cells are as sensitive as corresponding …

Drug-induced interphasic apoptosis in human leukemia cells is mediated through
intracellular signaling pathways, of which the most proximal (initiating) event remains …

A deficiency in apoptosis is one of the key events in the proliferation and resistance of
malignant cells to antitumor agents; for these reasons, the search for apoptosis-inducing …

Ceramide induces apoptosis in leukemia cell lines and has been proposed as a potential
therapeutic agent in malignancies refractory to conventional treatment. Here we show that …

Ceramide, a product of sphingolipid metabolism, is generated in response to various stress
stimuli, such as tumor necrosis factor-α, CD95/Fas, chemotherapeutic agents, and …

Recent data on the cellular ceramide functions and its involvement in the apoptotic/necrotic
cell death as well as its anticarcinogenic properties are presented. The emphasis is on the …

Simple Summary The sphingolipid ceramide is a key player in cytotoxic responses elicited
by many anticancer drugs. Confounding this asset, however, are enzymes that promote …