Plasma xanthine oxidoreductase activity as a novel biomarker of metabolic disorders in a general population

M Furuhashi, M Matsumoto, M Tanaka, N Moniwa… - Circulation …, 2018 - jstage.jst.go.jp
Background: Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of
uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive …

Independent association of plasma xanthine oxidoreductase activity with hypertension in nondiabetic subjects not using medication

M Furuhashi, Y Higashiura, M Koyama… - Hypertension …, 2021 - nature.com
Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation
in purine metabolism, is involved in reactive oxygen species generation. Plasma XOR …

Annual change in plasma xanthine oxidoreductase activity is associated with changes in liver enzymes and body weight

M Furuhashi, M Koyama, M Matsumoto, T Murase… - Endocrine …, 2019 - jstage.jst.go.jp
Xanthine oxidoreductase (XOR), an enzyme of uric acid formation from hypoxanthine and
xanthine, is recognized as a source of oxidative stress. Plasma activity of XOR has been …

Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans

KW Washio, Y Kusunoki, T Murase, T Nakamura… - Metabolism, 2017 - Elsevier
Abstract Background and Aims The enzyme xanthine oxidoreductase (XOR) catalyzes the
formation of uric acid (UA) from hypoxanthine and xanthine, which in turn are products of …

A highly sensitive assay of human plasma xanthine oxidoreductase activity using stable isotope-labeled xanthine and LC/TQMS

T Murase, M Nampei, M Oka, A Miyachi… - … of Chromatography B, 2016 - Elsevier
Associations between elevated plasma xanthine oxidoreductase (XOR) activity and various
pathologies have been widely reported. However, it has been difficult to accurately measure …

Independent association of plasma xanthine oxidoreductase activity with serum uric acid level based on stable isotope-labeled xanthine and liquid chromatography …

M Kurajoh, S Fukumoto, M Emoto, T Murase… - Clinical Chemistry and …, 2020 - degruyter.com
Background We developed a novel high-sensitive assay for plasma xanthine
oxidoreductase (XOR) activity that is not affected by the original serum uric acid level …

Relationship between plasma xanthine oxidoreductase activity and left ventricular ejection fraction and hypertrophy among cardiac patients

Y Fujimura, Y Yamauchi, T Murase, T Nakamura… - PLoS …, 2017 - journals.plos.org
Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine
catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase …

Association of plasma xanthine oxidoreductase activity with blood pressure affected by oxidative stress level: MedCity21 health examination registry

S Yoshida, M Kurajoh, S Fukumoto, T Murase… - Scientific reports, 2020 - nature.com
Xanthine oxidoreductase (XOR) inhibitor administration reduces uric acid and reactive
oxygen species (ROS) production, and also lowers blood pressure (BP). However, the …

Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients

A Nakatani, S Nakatani, E Ishimura, T Murase… - Scientific reports, 2017 - nature.com
Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of
reactive oxygen species. In the present study, we investigated factors associated with …

Differential regulation of hypoxanthine and xanthine by obesity in a general population

M Furuhashi, M Koyama, Y Higashiura… - Journal of diabetes …, 2020 - Wiley Online Library
Abstract Aims/Introduction Uric acid is synthesized by oxidation of hypoxanthine and
xanthine using a catalyzing enzyme, xanthine oxidoreductase (XOR), which can be a source …