The noradrenaline (norepinephrine) system exerts profound influences on cognition via
ascending projections to the forebrain, mostly originating from the locus coeruleus. This …

Norepinephrine released by the locus coeruleus modulates cellular processes and synaptic
transmission in the central nervous system through its actions at a number of pre‐and …

Norepinephrine (NE) has widespread projections throughout the brain, and thus, is ideally
positioned to orchestrate neural functions based on arousal state. For example, NE can …

This article aims to review research in nonhuman primates demonstrating that
norepinephrine can enhance the cognitive functioning of the prefrontal cortex through …

Mood, attention and motivation co-vary with activity in the neuromodulatory systems of the
brain to influence behaviour. These psychological states, mediated by neuromodulators …

Noradrenergic dysfunction may play a significant role in cognition in Parkinson's disease
due to the early degeneration of the locus coeruleus. Converging evidence from patient and …

Noradrenaline is implicated in the modulation of attention and arousal, but the
neuroanatomical basis of this effect in humans is unknown. A previous functional …

The concatenation of convergent lines of evidence from basic to clinical research continues
to reveal that norepinephrine (NE) is a crucial regulator of a myriad of behaviors ranging …

Rationale Noradrenaline (NA) is implicated in arousal. Working memory is dependent upon
prefrontal cortex, and moderate levels of NA are thought to facilitate working memory …

Both major depressive disorder and the anxiety disorders are major causes of disability and
markedly contribute to a significant global burden of the disease worldwide. In part because …