Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications

H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …

JAK/STAT signaling in hepatocellular carcinoma

JJ Hin Tang, DK Hao Thng, JJ Lim, TB Toh - Hepatic oncology, 2020 - Taylor & Francis
Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …

Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer

JJ Jia, X Zhou, Q Chu - Molecular and Cellular Biochemistry, 2024 - Springer
Liver cancer (LC) poses a significant global health challenge due to its high incidence and
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …

[HTML][HTML] Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma

S Yang, C Luo, Q Gu, Q Xu, G Wang, H Sun, Z Qian… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fifth most common type of cancers worldwide.
However, current therapeutic approaches for this epidemic disease are limited, and its 5 …

Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma

J Lokau, V Schoeder, J Haybaeck, C Garbers - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …

Ubiquitous activation of Ras and Jak/Stat pathways in human HCC

DF Calvisi, S Ladu, A Gorden, M Farina, EA Conner… - Gastroenterology, 2006 - Elsevier
Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …

Deciphering JAK/STAT signaling pathway: A multifaceted approach to tumorigenesis, progression and therapeutic interventions

Y Wang, Z Wang, S Li, J Ma, X Dai, J Lu - International …, 2024 - Elsevier
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway,
essential for cellular communication, orchestrates a myriad of physiological and pathological …

Janus Kinase 2 (JAK2) dissociates hepatosteatosis from hepatocellular carcinoma in mice

SY Shi, CT Luk, SA Schroer, MJ Kim… - Journal of Biological …, 2017 - ASBMB
Hepatocellular carcinoma is an end-stage complication of non-alcoholic fatty liver disease
(NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver …

Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma

X Wang, X Liao, T Yu, Y Gong… - International …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor
prognosis in patients. The aim of the present study is to explore the clinical significance of …

Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy

IH Mir, S Guha, J Behera… - Cell Biology …, 2021 - Wiley Online Library
Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating
cause of mortality associated with cancer worldwide. The development of hepatocellular …