Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications
H Park, S Lee, J Lee, H Moon, SW Ro - International Journal of Molecular …, 2023 - mdpi.com
Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …
due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase …
JAK/STAT signaling in hepatocellular carcinoma
JJ Hin Tang, DK Hao Thng, JJ Lim, TB Toh - Hepatic oncology, 2020 - Taylor & Francis
Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …
Mechanisms and therapeutic prospect of the JAK-STAT signaling pathway in liver cancer
JJ Jia, X Zhou, Q Chu - Molecular and Cellular Biochemistry, 2024 - Springer
Liver cancer (LC) poses a significant global health challenge due to its high incidence and
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …
poor prognosis. Current systemic treatment options, such as surgery, chemotherapy …
[HTML][HTML] Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma
S Yang, C Luo, Q Gu, Q Xu, G Wang, H Sun, Z Qian… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fifth most common type of cancers worldwide.
However, current therapeutic approaches for this epidemic disease are limited, and its 5 …
However, current therapeutic approaches for this epidemic disease are limited, and its 5 …
Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. It
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …
can be caused by chronic liver cell injury with resulting sustained inflammation, eg, triggered …
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
DF Calvisi, S Ladu, A Gorden, M Farina, EA Conner… - Gastroenterology, 2006 - Elsevier
Background & Aims: Although the natural history and pathologic characteristics of human
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …
hepatocellular carcinoma (HCC) are well documented, the molecular pathogenesis of HCC …
Deciphering JAK/STAT signaling pathway: A multifaceted approach to tumorigenesis, progression and therapeutic interventions
Y Wang, Z Wang, S Li, J Ma, X Dai, J Lu - International …, 2024 - Elsevier
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway,
essential for cellular communication, orchestrates a myriad of physiological and pathological …
essential for cellular communication, orchestrates a myriad of physiological and pathological …
Janus Kinase 2 (JAK2) dissociates hepatosteatosis from hepatocellular carcinoma in mice
SY Shi, CT Luk, SA Schroer, MJ Kim… - Journal of Biological …, 2017 - ASBMB
Hepatocellular carcinoma is an end-stage complication of non-alcoholic fatty liver disease
(NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver …
(NAFLD). Inflammation plays a critical role in the progression of non-alcoholic fatty liver …
Analysis of clinical significance and prospective molecular mechanism of main elements of the JAK/STAT pathway in hepatocellular carcinoma
X Wang, X Liao, T Yu, Y Gong… - International …, 2019 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is one the most common malignancies and has poor
prognosis in patients. The aim of the present study is to explore the clinical significance of …
prognosis in patients. The aim of the present study is to explore the clinical significance of …
Targeting molecular signal transduction pathways in hepatocellular carcinoma and its implications for cancer therapy
IH Mir, S Guha, J Behera… - Cell Biology …, 2021 - Wiley Online Library
Hepatocellular carcinoma is a substantial health concern. It is currently the third dominating
cause of mortality associated with cancer worldwide. The development of hepatocellular …
cause of mortality associated with cancer worldwide. The development of hepatocellular …