The features of JAK-STAT signaling in liver cells are discussed in the current review. The
role of this signaling cascade in carcinogenesis is accentuated. The possible involvement of …

Abstract The Janus kinases (JAKs) and signal transducer and activator of transcription
(STAT) proteins, particularly STAT3, are among the most promising new targets for cancer …

Aberrant activation of signal transducer and activator of transcription (STAT) proteins is
associated with the development and progression of solid tumors. However, as transcription …

Background: JAK/STAT signal pathway, a requisite part in the signaling process of growth
factors and cytokines, has become attractive targets for numerous immune, inflammatory …

Introduction: Hepatocellular carcinoma (HCC) is a significant problem globally because of
viral infections and the increasing incidence of obesity and fatty liver disease. However, it is …

Constitutive JAK-STAT signaling drives the proliferation of most myeloproliferative
neoplasms (MPN) and a subset of acute myeloid leukemia (AML), but persistence emerges …

Antibodies that block cytokine function provide a powerful therapeutic tool especially for the
treatment of autoimmune diseases. Cytokines are a group of small hydrophilic glycoproteins …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway is one
of the key signaling cascades in cholangiocarcinoma (CCA) cells, mediating their resistance …

Conventional systemic chemotherapy has been developed with so-called anti-cancer
agents, essentially screened for cytotoxicity to cultured cancer cells. However, in patients …

Protein tyrosine kinases belonging to the Janus kinase (JAK) family are associated with
many cytokine receptors, which, on ligand binding, regulate important cellular functions such …