Suppressors of cytokine signaling and hepatocellular carcinoma
R Masuzaki, T Kanda, R Sasaki, N Matsumoto, K Nirei… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a common malignancy worldwide. The
HCC generally develops in the liver of patients already suffering from chronic liver disease …
HCC generally develops in the liver of patients already suffering from chronic liver disease …
The JAK-STAT pathway: impact on human disease and therapeutic intervention
JJ O'Shea, DM Schwartz, AV Villarino… - Annual review of …, 2015 - annualreviews.org
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
[HTML][HTML] Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges
MDA Paskeh, F Ghadyani, M Hashemi… - Pharmacological …, 2023 - Elsevier
Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …
Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
H Fuke, K Shiraki, K Sugimoto, J Tanaka… - Biochemical and …, 2007 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in
various cancers and plays a crucial role in oncogensis, including the activation of genes …
various cancers and plays a crucial role in oncogensis, including the activation of genes …
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential
HT Tzeng, IT Chyuan, JH Lai - Biochemical Pharmacology, 2021 - Elsevier
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
pathway is characterized by diverse immune regulatory systems involving cell proliferation …
[HTML][HTML] Pathogenesis to management of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver cancer whose incidence
continues to rise in many parts of the world due to a concomitant rise in many associated risk …
continues to rise in many parts of the world due to a concomitant rise in many associated risk …
[PDF][PDF] RETRACTED ARTICLE: IL-6/STAT3 Signaling Contributes to Sorafenib Resistance in Hepatocellular Carcinoma Through Targeting Cancer Stem Cells
Li Y, Chen G, Han Z, Cheng H, Qiao L, Li Y. Onco Targets Ther. 2020; 13: 9721–9730. The
Editor and Publisher of OncoTargets and Therapy wish to retract the published article …
Editor and Publisher of OncoTargets and Therapy wish to retract the published article …
[PDF][PDF] Blockade of Janus kinase‐2 signaling ameliorates mouse liver damage due to ischemia and reperfusion
MCS Freitas, Y Uchida, D Zhao, B Ke… - Liver …, 2010 - Wiley Online Library
Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is one
of the major pathways for cytokine signal transduction. However, the role of the JAK/STAT …
of the major pathways for cytokine signal transduction. However, the role of the JAK/STAT …
Targeting the JAK/STAT signaling pathway for breast cancer
F Shao, X Pang, GH Baeg - Current medicinal chemistry, 2021 - ingentaconnect.com
Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of
treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable …
treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable …
[HTML][HTML] Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death
L Xie, Y Zeng, Z Dai, W He, H Ke, Q Lin… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) has become the second leading cause of cancer related
death, with an increasing death rate in recent years. For advanced HCC, sorafenib is the first …
death, with an increasing death rate in recent years. For advanced HCC, sorafenib is the first …