Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

Growth and development of embryonic organs goes hand in hand with development of the
vascular system. Blood vessels have been known for centuries to supply nutrients and …

Blood vessels form a highly branched, interconnected, and largely stereotyped network of
tubes that sustains every organ and tissue in vertebrates. How vessels come to take on their …

How organ size and form are controlled during development is a major question in biology.
Blood vessels have been shown to be essential for early development of the liver and …

The vertebrate pancreas is comprised of a highly branched tubular epithelium, which is
intimately associated with an extensive and specialized vasculature. While we know a great …

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to
form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels …

Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification,
and endocrine function. They are also involved in the physiopathology of type 1 and type 2 …

Endothelial cells are required to initiate pancreas development from the endoderm. They
also control the function of endocrine islets after birth. Here we investigate in developing …

Neurovascular alignment is a common anatomical feature of organs, but the mechanisms
leading to this arrangement are incompletely understood. Here, we show that vascular …

Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …