Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate
a role for blood vessels as a source of developmental signals during pancreatic …

Understanding the tissue interactions that induce pancreatic progenitor cells from the
embryonic endoderm provides insights into congenital malformations, tissue repair, and …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

The vasculature of an organism has the daunting task of connecting all the organ systems to
nourish tissue and sustain life. This complex network of vessels and associated cells must …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

Endoderm development is dependent on inductive signals from different structures in close
vicinity, including the notochord, lateral plate mesoderm and endothelial cells. Recently, we …

Liver and pancreas initially develop by budding from the embryonic endoderm. The
formation of these organs coincides with the appearance of endothelial cells (ECs) adjacent …

The mechanisms underlying early islet graft failure are not entirely clear, but are thought to
involve ischemic injury due to delayed vascularization. We hypothesize that blood vessels …

Dorsal and ventral pancreatic bud development from the endoderm requires inductive
interactions with diverse mesodermal cell types and the action of transcription factors …

The developing pancreatic epithelium gives rise to all endocrine and exocrine cells of the
mature organ. During organogenesis, the epithelial cells receive essential signals from the …