Blood vessels perfuse all tissues in the body and mediate vital metabolic exchange between
tissues and blood. Increasing evidence, however, points to a direct role for paracrine …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …

The mechanisms underlying zebrafish pancreatic islet vascularization have not been well
characterized. We sought to determine the angiogenic factors responsible for islet …

The relentless nature and increasing prevalence of human pancreatic diseases, in
particular, diabetes mellitus and adenocarcinoma, has motivated further understanding of …

In the developing embryo, appropriate patterning of the endoderm fated to become
pancreas requires the spatial and temporal coordination of soluble factors secreted by the …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Beyond its role as an electron acceptor in aerobic respiration, oxygen is also a key effector
of many developmental events. The oxygen‐sensing machinery and the very fabric of cell …

The formation of the vertebrate pancreas is a complex process that typifies the basic steps of
embryonic development. It involves the establishment of competence, specification …