The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

Maintenance of glucose homeostasis depends on adequate amount and precise pattern of
insulin secretion, which is determined by both β-cell secretory processes and well …

Arteriogenesis rather than unspecialized capillary expansion is critical for restoring effective
circulation to compromised tissues in patients. Deciphering the origin and specification of …

Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial
cells, which will form the exocrine and endocrine cells of the adult organ, with their …

During pancreas development, epithelial buds undergo branching morphogenesis to form
an exocrine and endocrine gland. Proper morphogenesis is necessary for correct lineage …

The aim of the present study was to investigate possible changes in the islet
microvasculature during the period of pronounced β‐cell growth seen perinatally in rats. We …

Although endothelial cells have been shown to affect mouse pancreatic development, their
precise function in human development remains unclear. Using a coculture system …

Adult organs are vascularized by specialized blood vessels. In addition to inter-organ
vascular heterogeneity, each organ is arborized by structurally and functionally diversified …

Vertebrate development depends on the formation of intricate vascular networks at
numerous sites and in precise patterns; these vascular networks supply oxygen and …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …