Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

A better understanding of processes controlling the development and function of pancreatic
islets is critical for diabetes prevention and treatment. Here, we reveal a previously …

Pancreas organogenesis is a highly dynamic process where neighboring tissue interactions
lead to dynamic changes in gene regulatory networks that orchestrate endocrine, exocrine …

Maintenance of blood vessel integrity is crucial for vascular homeostasis and is mainly
controlled at the level of endothelial cell (EC) junctions. Regulation of endothelial integrity …

The vascular system forms as a branching network of endothelial cells that acquire identity
as arterial, venous, hemogenic, or lymphatic. Endothelial specification depends on gene …

Objective The maintenance and expansion of β-cell mass rely on their proliferation, which
reaches its peak in the neonatal stage. β-cell proliferation was found to rely on cells of the …

It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …

Current differentiation protocols have not been successful in reproducibly generating fully
functional human beta cells in vitro, partly due to incomplete understanding of human …

The mammalian pancreas is a highly branched gland, essential for both digestion and
glucose homeostasis. Pancreatic branching, however, is poorly understood, both at the …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …