The interplay between pancreatic epithelium and the surrounding microenvironment is
pivotal for pancreas formation and differentiation as well as adult organ homeostasis. The …

Background: In mice, the intestinal tube develops from the splanchopleure before embryonic
day 9.5. Subsequent patterning of nerves and blood vessels is critical for normal digestive …

Blood vessel development is a vital process during embryonic development, during tissue
growth, regeneration and disease processes in the adult. In the past decade researchers …

The correct development of blood vessels is crucial for all aspects of tissue growth and
physiology in vertebrates. The formation of an elaborate hierarchically branched network of …

Throughout embryogenesis, establishment of the vascular network is mediated by a
complex and highly regulated interplay between positive and negative growth factors. In …

Within a day of gastrulation, the embryonic heart begins to beat and creates blood flow in the
developing cardiovascular system. The onset of blood flow completely changes the …

It is generally accepted that vascularization and oxygenation of pancreatic islets are
essential for the maintenance of an optimal β-cell mass and function and that signaling by …

▪ Abstract Regulated assembly of a highly specialized interconnecting network of vascular
endothelial and supportive cells is fundamental to embryonic development and …

Reliance on rodents for understanding pancreatic genetics, development and islet function
could limit progress in developing interventions for human diseases such as diabetes …

The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …