Osteoarthritis (OA) is the most common chronic joint disease in the elderly population,
causing significant pain and disability. Because the cardinal feature of OA is a progressive …

Osteoarthritis (OA) is the most common chronic joint disorder found in the aging population
and is primarily characterized by loss of articular cartilage. Because chondrocytes are …

Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Articular cartilage is a highly specialized and uniquely structured biomaterial that forms the
smooth, gliding surface of the diarthrodial joints. It consists of an extracellular matrix that is …

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage
degradation and changes in the subchondral bone. Over the last two decades, there has …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

Osteoarthritis (OA) is the most common joint disease characterised by degradation of
articular cartilage and bone remodelling. For almost a decade chondrocyte apoptosis has …

Osteoarthritic cartilage degeneration is largely a process of destruction and failure of the
extracellular matrix. The matrix turnover, however, including anabolic regeneration, depends …

Apoptotic death of articular chondrocytes has been implicated in the pathogenesis of human
osteoarthritis. Although nitric oxide and Fas ligand have been shown to be inducers of …