Our aim was to understand the mechanism of immunological changes associated with the
use of an adsorptive-type extracorporeal device (Adacolumn) that has been developed for …

BACKGROUND.: Recent evidence suggests that peripheral blood granulocytes and
monocytes/macrophages have a major role in the exacerbation of ulcerative colitis. AIMS …

Active ulcerative colitis (UC) is characterized by activation and infiltration of granulocytes
and monocytes/macrophages into the colonic mucosa. The infiltrated leukocytes can cause …

Ulcerative colitis (UC) is a chronic and recurrent inflammatory bowel disease that appears
with varying severity. The disease is associated with activation of the immune system and …

Background & Aims: Active ulcerative colitis (UC) is characterized by infiltration of activated
granulocytes and monocytes/macrophages (GM) within the large bowel mucosa. GM are …

We have studied the effects of granulocyte apheresis in 18 patients with ulcerative colitis
and 6 with Crohn's disease who had failed to respond to conventional therapy. Patients …

Active ulcerative colitis (UC) is frequently associated with infiltration of a large number of
leukocytes into the bowel mucosa. Therefore, removal of activated circulating leukocytes by …

Recently, selective granulocytapheresis (Adacolumn) has appeared as a new treatment for
patients with inflammatory bowel disease. This study sought to determine predictors of …

Adacolumn selective granulocyte and monocyte apheresis (GMA) depletes activated
leukocytes in patients with ulcerative colitis (UC). However, this per se cannot fully explain …

BACKGROUND & AIMS: Activated granulocytes and monocytes/macrophages are
implicated in the pathogenesis of ulcerative colitis. Open-label studies and clinical …