This systematic review summarizes pharmacogenetic studies on antidepressant response
and side effects. Out of the 17 genes we reviewed, 8 genes were entered into the meta …

A number of candidate gene studies focused on major depression (MD) and antidepressant
(AD) efficacy have been carried out, but results mainly remain inconclusive. We performed a …

The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly
associated with antidepressant response in mood disorder patients, but findings are not …

In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

BACKGROUND: The serotonin transporter gene-linked polymorphic region (5-HTTLPR) has
been proposed as a predictor of antidepressant response. Insertion or deletion of a 44-base …

The pharmacogenetics of antidepressants has been not only a challenging but also
frustrating research field since its birth in the 1990s. Indeed, great expectations followed the …

BACKGROUND: The short (S) allele of the serotonin transporter gene-linked polymorphic
region (5HTTLPR) has been associated with poorer antidepressant response in major …

Large differences in clinical response to selective serotonin reuptake inhibitors (SSRIs) are
observed in depressive patients with different genotypes. Quantification of these differences …

The majority of antidepressant drugs act by increasing synaptic serotonin levels in the brain.
Genetic variation in serotonin-related genes may therefore influence antidepressant efficacy …

Variability in antidepressant response is due to genetic and environmental factors. Among
genetic factors, the ones controlling for availability of the drug at the target site are …