Characterization and Reliability of [18F]2FNQ1P in Cynomolgus Monkeys as a PET Radiotracer for Serotonin 5-HT6 Receptors
V Sgambato-Faure, T Billard, E Météreau… - Frontiers in …, 2017 - frontiersin.org
Brain serotonin-6 receptor (5-HT6R) is the one of the most recently identified serotonin
receptors. Accumulating evidence suggests that it is a potent therapeutic target for …
receptors. Accumulating evidence suggests that it is a potent therapeutic target for …
[HTML][HTML] Preclinical evaluation of [18F]2FNQ1P as the first fluorinated serotonin 5-HT6 radioligand for PET imaging
G Becker, J Colomb, V Sgambato-Faure… - European journal of …, 2015 - Springer
Abstract Purpose Brain serotonin 6 receptor (5-HT 6) is one of the most recently identified
serotonin receptors. It is a potent therapeutic target for psychiatric and neurological …
serotonin receptors. It is a potent therapeutic target for psychiatric and neurological …
Preclinical validation of [18F] 2FNQ1P as a specific PET radiotracer of 5-HT6 receptors in rat, pig, non-human primate and human brain tissue
S Emery, S Fieux, B Vidal, P Courault… - Nuclear Medicine and …, 2020 - Elsevier
Introduction The aim of this study was to perform in-vitro and in-vivo radiopharmacological
characterizations of [18 F] 2FNQ1P, a new PET radiotracer of 5-HT 6 receptors, in rat, pig …
characterizations of [18 F] 2FNQ1P, a new PET radiotracer of 5-HT 6 receptors, in rat, pig …
Comparison of 4 radiolabeled antagonists for serotonin 5-HT7 receptor neuroimaging: toward the first PET radiotracer
L Lemoine, J Andries, D Le Bars, T Billard… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Brain serotonin 7 (5-hydroxytryptamine 7, or 5-HT7) is the most recently identified serotonin
receptor. It is involved in mood disorders and is studied as a target for antidepressants …
receptor. It is involved in mood disorders and is studied as a target for antidepressants …
Synthesis and biological evaluation in rat and cat of [18F] 12ST05 as a potential 5-HT6 PET radioligand
S Tang, M Verdurand, B Joseph, L Lemoine… - Nuclear medicine and …, 2007 - Elsevier
INTRODUCTION: 5-hydroxytryptamine (5-HT) 6 receptors represent one of the more recently
discovered serotoninergic receptor family. However, no 5-HT6 positron emission …
discovered serotoninergic receptor family. However, no 5-HT6 positron emission …
Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging
J Colomb, G Becker, E Forcellini, S Meyer… - Nuclear Medicine and …, 2014 - Elsevier
Introduction The brain serotonin-7 receptor (5-HT 7) is the most recently discovered
serotonin receptor. It is targeted by several drug-candidates in psychopharmacology and …
serotonin receptor. It is targeted by several drug-candidates in psychopharmacology and …
Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers
Abstract Brain serotonin 7 receptor (5-HT 7) is involved in several mood disorders and drug
candidates targeting this subtype are currently in development. Positron emission …
candidates targeting this subtype are currently in development. Positron emission …
Initial evaluation of [18F] F13714, a novel 5-HT1A receptor agonist in non-human primates
Aim. Brain serotonin 1A receptors (5-HT1A) exist in high-and low-affinity states. It is known
that agonists bind preferentially to the high-affinity state of the receptors and therefore could …
that agonists bind preferentially to the high-affinity state of the receptors and therefore could …
[HTML][HTML] 18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging
B Vidal, S Fieux, M Colom, T Billard, C Bouillot… - Brain Structure and …, 2018 - Springer
Serotonin 1A receptors are known to play an important role in many psychiatric and
neurodegenerative disorders. Currently, all available 5-HT 1A receptor PET …
neurodegenerative disorders. Currently, all available 5-HT 1A receptor PET …
Syntheses, Radiolabelings, and in Vitro Evaluations of Fluorinated PET Radioligands of 5-HT6 Serotoninergic Receptors
The 5-HT6 receptors are potent therapeutic targets for psychiatric and neurological diseases
(schizophrenia, Alzheimer's disease, etc.). However, with lack of specific …
(schizophrenia, Alzheimer's disease, etc.). However, with lack of specific …