Listeria monocytogenes infection induces a strong inflammatory response characterized by
the production of IL-12 and IFN-γ and protective immunity against this pathogen is …

IL-10 is an important immunoregulatory cytokine that plays a central role in maintaining a
balance between protective immunity against infection and limiting proinflammatory …

We have studied IL-12p35-deficient (IL-12p35–/–) mice to evaluate the role of IL-12 in
resistance against Listeria monocytogenes. In the absence of bioactive IL-12p75, mutant …

We recently constructed IL‐15 transgenic (Tg) mice using cDNA encoding a secretable
isoform of the IL‐15 precursor protein under the control of an MHC class I promoter. The IL …

Interferon (IFN)-γ plays an important role in the innate immune response against intracellular
bacterial pathogens. It is commonly thought that natural killer cells are the primary source of …

Mice infected with virulent Listeria monocytogenes develop long-lived acquired immunity.
We previously reported that acquired immunity to Listeria could also be elicited by …

CD4 T cells are known to assist the CD8 T cell response by activating APC via CD40-CD40
ligand (L) interactions. However, recent data have shown that bacterial products can directly …

Proinflammatory cytokines, such as gamma interferon (IFN-γ), impact aspects of T-cell
responses after infection, including expansion, contraction, and memory formation …

Listeria monocytogenes (LM) is a Gram-positive, intracellular bacterium that can induce
spontaneous abortion, septicemia, and meningitis. Although it is known that neutrophils are …

The stimulation of interferon (IFN)-γ by interleukin (IL)-12 has been shown to provide
protection from intracellular pathogens such as Listeria monocytogenes. Tumor necrosis …