Galanin over-expression decreases the development of neuropathic pain-like behaviors in mice after partial sciatic nerve injury
K Hygge-Blakeman, P Brumovsky, JX Hao, XJ Xu… - Brain research, 2004 - Elsevier
The neuropeptide galanin may have a role in modulation of nociception, particularly after
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
peripheral nerve injury. Here we assessed the development of neuropathic pain-like …
Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
BJ Kerr, WBJ Cafferty, YIK Gupta… - European Journal of …, 2000 - Wiley Online Library
The neuropeptide galanin has been identified as a potential neurotransmitter/
neuromodulator within the central nervous system. In the present study, the role of …
neuromodulator within the central nervous system. In the present study, the role of …
Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury
FE Holmes, SA Mahoney, D Wynick - Neuropeptides, 2005 - Elsevier
The neuropeptide galanin is present at high levels within the dorsal root ganglia (DRG) and
spinal cord during development and after peripheral nerve damage in the adult. This pattern …
spinal cord during development and after peripheral nerve damage in the adult. This pattern …
Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse—possible implications for pain processing
P Brumovsky, K Hygge-Blakeman, MJ Villar… - Journal of Chemical …, 2006 - Elsevier
The distribution of galanin was studied in the lumbar 5 dorsal root ganglia (DRGs) and
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
spinal cord, superior cervical ganglia (SCGs), and skin of transgenic mice overexpressing …
Intrathecal galanin alleviates allodynia‐like behaviour in rats after partial peripheral nerve injury
JX Hao, TJ Shi, IS Xu, T Kaupilla, XJ Xu… - European Journal Of …, 1999 - Wiley Online Library
We have previously suggested that the neuropeptides galanin and galanin message‐
associated peptide (GMAP) may have an inhibitory role in spinal nociception. The present …
associated peptide (GMAP) may have an inhibitory role in spinal nociception. The present …
Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice
RJP Pope, FE Holmes, NC Kerr, D Wynick - Molecular Pain, 2010 - journals.sagepub.com
The neuropeptide galanin is widely expressed in both the central and peripheral nervous
systems and is involved in many diverse biological functions. There is a substantial data set …
systems and is involved in many diverse biological functions. There is a substantial data set …
Transgenic over-expression of galanin in injured primary sensory neurons
A Bacon, FE Holmes, CJ Small, M Ghatei… - …, 2002 - journals.lww.com
The 29 amino acid neuropeptide galanin is normally expressed in< 5% of sensory neurons
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
in the adult dorsal root ganglia. After nerve transection (axotomy), the galanin content of the …
The participation of galanin in pain processing at the spinal level
Abstract Galanin, a 29-amino-acid peptide expressed in dorsal root ganglia (DRG) and
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
spinal dorsal horn interneurones, is regulated by nerve injury and peripheral inflammation …
Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior
FE Holmes, A Bacon, RJP Pope… - Proceedings of the …, 2003 - National Acad Sciences
The neuropeptide galanin is expressed in the dorsal root ganglia (DRG) and spinal cord and
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
is thought to be involved in the modulation of pain processing. However, its mechanisms of …
Generation and phenotypic characterization of a galanin overexpressing mouse
K Holmberg, E Kuteeva, P Brumovsky, U Kahl… - Neuroscience, 2005 - Elsevier
In most parts of the peripheral nervous system galanin is expressed at very low levels. To
further understand the functional role of galanin, a mouse overexpressing galanin under the …
further understand the functional role of galanin, a mouse overexpressing galanin under the …