Inflammatory mediators released during acute and chronic diseases activate multiple
intracellular signalling cascades including the mitogen-activated protein kinase (MAPK) …

Inflammation is a natural host defensive process that is largely regulated by macrophages
during the innate immune response. Mitogen‐activated protein kinases (MAPKs) are proline …

Excessive inflammation is becoming accepted as a critical factor in many human diseases,
including inflammatory and autoimmune disorders, neurodegenerative conditions, infection …

Chronic inflammatory processes are based on a sustained and tightly regulated
communication network among different cells types. This network comprises extracellular …

Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

Objective Activation of p38 MAPK is a key signaling step in chronic inflammation. Inhibition
of p38 MAPK is considered to be a promising future strategy to control inflammatory …

The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase
(MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most …

The mitogen-activated protein kinase (MAPK) p38 is a Ser/Thr kinase, originally isolated
from lipopolysaccharide-stimulated monocytes. There are four isoforms of the enzyme …