In this study, we investigated the association between altered methylation in the maternal
placenta and hyperglycaemia and explored the epigenetic mechanisms underlying …

Emerging evidences indicate that placenta plays a critical role in gestational diabetes
mellitus (GDM). DNA methylation could be associated with altered placental development …

Gestational diabetes mellitus (GDM)“program” an elevated risk of metabolic syndrome in the
offspring. Epigenetic alterations are a suspected mechanism. GDM has been associated …

Background Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease
and is growing at an alarming rate worldwide, which can negatively affect the health of …

Diabetes in pregnancy is associated with adverse pregnancy outcomes and poses a serious
threat to the health of mother and child. Although the pathophysiological mechanisms that …

Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Maternal diabetes and/or obesity in pregnancy are undoubtedly associated with later
disease-risk in the offspring. The placenta, interposed between the mother and the foetus, is …

Aims/hypothesis Individuals exposed to maternal diabetes in utero are more likely to
develop metabolic and cardiovascular diseases later in life. This may be partially attributable …

Background Studies have shown that the effects of maternal nutrition exposure during
gestation influence metabolic risk in early life through an epigenetic mechanism. Low …

Background In utero exposure to diabetes has been shown to contribute to preterm birth,
though the underlying biological mechanisms are yet to be fully elucidated. Fetal epigenetic …