Constituent of innate immunity, complement is present in the tumor microenvironment. The
functions of complement include clearance of pathogens and maintenance of homeostasis …

The role of complement in cancer has received increasing attention over the last decade.
Recent studies provide compelling evidence that complement accelerates cancer …

Despite significant research on the role of inflammation and immunosurveillance in the
immunologic microenvironment of tumors, little attention has been given to the oncogenic …

The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Complement is a central part of the immune system that has developed as a first defense
against non-self cells. Neoplastic transformation is accompanied by an increased capacity of …

Constituting a part of the innate immune system, the complement system consists of over 50
proteins either acting as part of a 3-branch activation cascade, a well-differentiated …

Several studies of human cancers have established that chronic and insidious inflammation
promotes the process of carcinogenesis and exacerbates the growth of existing tumors …

For decades, complement has been recognized as an effector arm of the immune system
that contributes to the destruction of tumor cells. In fact, many therapeutic strategies have …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Chronic inflammation has been linked to the initiation of carcinogenesis, as well as the
advancement of established tumors. The polarization of the tumor inflammatory …