Therapeutic translation in acute kidney injury: the epithelial/endothelial axis
BA Molitoris - The Journal of clinical investigation, 2014 - Am Soc Clin Investig
Acute kidney injury (AKI) remains a major clinical event with rising incidence, severity, and
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …
cost; it now has a morbidity and mortality exceeding acute myocardial infarction. There is …
Cellular pathophysiology of ischemic acute kidney injury
JV Bonventre, L Yang - The Journal of clinical investigation, 2011 - Am Soc Clin Investig
Ischemic kidney injury often occurs in the context of multiple organ failure and sepsis. Here,
we review the major components of this dynamic process, which involves hemodynamic …
we review the major components of this dynamic process, which involves hemodynamic …
Renal endothelial injury and microvascular dysfunction in acute kidney injury
SK Verma, BA Molitoris - Seminars in nephrology, 2015 - Elsevier
The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …
a number of tightly controlled, complex and interdependent processes. Renal endothelial …
Acute kidney injury
A Zuk, JV Bonventre - Annual review of medicine, 2016 - annualreviews.org
Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …
Pathogenesis of acute kidney injury: foundation for clinical practice
GR Kinsey, MD Okusa - American Journal of Kidney Diseases, 2011 - Elsevier
The pathogenesis of acute kidney injury (AKI) is complex, involving such factors as
vasoconstriction, leukostasis, vascular congestion, cell death, and abnormal immune …
vasoconstriction, leukostasis, vascular congestion, cell death, and abnormal immune …
Renal endothelial dysfunction in acute kidney ischemia reperfusion injury
Acute kidney injury is associated with alterations in vascular tone that contribute to an
overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations …
overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations …
Pathophysiology of ischaemic acute kidney injury
NS Kanagasundaram - Annals of clinical biochemistry, 2015 - journals.sagepub.com
Acute kidney injury is common, dangerous and costly, affecting around one in five patients
emergency admissions to hospital. Although survival decreases as disease worsens, it is …
emergency admissions to hospital. Although survival decreases as disease worsens, it is …
Pathophysiology of ischemic acute kidney injury
AA Sharfuddin, BA Molitoris - Nature Reviews Nephrology, 2011 - nature.com
Acute kidney injury (AKI) as a consequence of ischemia is a common clinical event leading
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
to unacceptably high morbidity and mortality, development of chronic kidney disease (CKD) …
Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease
A Zuk, JV Bonventre - Current opinion in nephrology and …, 2019 - journals.lww.com
Recent advances in acute kidney injury and its consequences... : Current Opinion in
Nephrology and Hypertension Recent advances in acute kidney injury and its …
Nephrology and Hypertension Recent advances in acute kidney injury and its …
[HTML][HTML] Mechanisms and therapeutic targets of ischemic acute kidney injury
SJ Han, HT Lee - Kidney research and clinical practice, 2019 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …
without effective therapy and is a significant and frequent cause of morbidity and mortality …