[HTML][HTML] Blood–brain barrier disruption and its involvement in neurodevelopmental and neurodegenerative disorders

A Aragón-González, PJ Shaw, L Ferraiuolo - International journal of …, 2022 - mdpi.com
The blood–brain barrier (BBB) is a highly specialized and dynamic compartment which
regulates the uptake of molecules and solutes from the blood. The relevance of the …

[HTML][HTML] Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders

HK Alajangi, M Kaur, A Sharma, S Rana, S Thakur… - Molecular Brain, 2022 - Springer
The integrity of the blood–brain barrier (BBB) is essential for normal central nervous system
(CNS) functioning. Considering the significance of BBB in maintaining homeostasis and the …

Basic physiology of the blood-brain barrier in health and disease: a brief overview

M Kaya, B Ahishali - Tissue Barriers, 2021 - Taylor & Francis
The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …

Blood‐brain barrier overview: structural and functional correlation

A Alahmari - Neural plasticity, 2021 - Wiley Online Library
The blood‐brain barrier (BBB) is a semipermeable and extremely selective system in the
central nervous system of most vertebrates, that separates blood from the brain's …

Development of novel therapeutics targeting the blood–brain barrier: from barrier to carrier

J Li, M Zheng, O Shimoni, WA Banks, AI Bush… - Advanced …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

[HTML][HTML] The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

[HTML][HTML] Mechanistic insights, treatment paradigms, and clinical progress in neurological disorders: current and future prospects

S Alkahtani, NS Al-Johani, S Alarifi - International Journal of Molecular …, 2023 - mdpi.com
Neurodegenerative diseases (NDs) are a major cause of disability and are related to brain
development. The neurological signs of brain lesions can vary from mild clinical shortfalls to …

[HTML][HTML] Study of BBB dysregulation in neuropathogenicity using integrative human model of blood–brain barrier

C Simöes Da Gama, M Morin-Brureau - Frontiers in Cellular …, 2022 - frontiersin.org
The blood–brain barrier (BBB) is a cellular and physical barrier with a crucial role in
homeostasis of the brain extracellular environment. It controls the imports of nutrients to the …

[HTML][HTML] Blood-brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders

M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang - Frontiers in Neuroscience, 2020 - frontiersin.org
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …

[HTML][HTML] Damage mechanism and therapy progress of the blood-brain barrier after ischemic stroke

H Gao, H Chen, GY Cui, JX Hu - Cell & Bioscience, 2023 - Springer
The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous
system, while also maintaining micro-environment homeostasis and inhibiting harmful …