Early in embryogenesis, cells that are destined to become germ cells take on a different
destiny from other cells in the embryo. The germ cells are not programmed to perform “vital” …

Male infertility is a heterogeneous condition of largely unknown etiology that affects at least
7% of men worldwide. Classical genetic approaches and emerging next-generation …

Infertility affects an estimated 10% of couples, and in roughly half of these cases the defect
can be traced to the man. Several groups have expressed the concern that male-infertility …

Nearly 7% of men suffer from male factor infertility. In one-fourth of infertile males, the
etiology remains unexplained. Unlike other multifactorial disorders, gene-gene and gene …

It has been argued that about 4–5% of male adults suffer from infertility due to a genetic
causation. From studies in the fruitfly Drosophila, there is evidence that up to 1500 recessive …

Approximately 80 million people worldwide are infertile, and nearly half of all infertility cases
are attributed to a male factor. Therefore, progress in reproductive genetics becomes crucial …

Male infertility is a common and complex disease, manifesting as a wide range of
phenotypes, ranging from apparently normal semen parameters with an inexplicable …

Approximately 1 in 6 couples in the Western world is not able to conceive spontaneously
after 1 year of unprotected intercourse; in nearly half of these couples, the male partner has …

Our understanding of male fertility has increased dramatically over the past several
decades, in large part because of advances in technology and the ability to rapidly analyze …

Spermatogenesis is a complex process that involves stem-cell renewal, genome
reorganization and genome repackaging, and that culminates in the production of motile …