Peripheral glucocorticoid receptors (GRs) play a significant role in the anti-inflammatory
effects of glucocorticoids; however, the role of central GRs in nociceptive behaviors after …

Central glucocorticoid receptors (GRs) and NMDA receptors (NMDARs) have been shown to
play a significant role in the mechanisms of neuropathic pain after peripheral nerve injury; …

Background In naive rats, corticosteroids activate neuronal membrane–bound glucocorticoid
and mineralocorticoid receptors in spinal cord and periphery to modulate nociceptive …

Injury to the spinal nerves of mice induces mechanical allodynia and thermal hyperalgesia.
In the injured spinal cord, the expression of glucocorticoid receptor mRNA was increased …

There is growing recognition that psychological stress influences pain. Hormones that
comprise the physiological response to stress (eg, corticosterone; CORT) may interact with …

Glucocorticoids were long believed to primarily function through cytosolic glucocorticoid
receptor (GR) activation and subsequent classical genomic pathways. Recently, however …

Glucocorticoids are used to treat patients suffering from neuropathic pain and complex
regional pain syndromes (CRPS). Previously we found that once-daily injections of the …

High levels of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) are
colocalized in the substantia gelatinosa. This indicates that the pain pathways appear to be …

Many neurotransmitters involved in pain perception transmit signals via G protein-coupled
receptors (GPCRs). GPCR kinase 2 (GRK2) regulates agonist-induced desensitization and …

Glucocorticoids improve the symptoms of peripheral nerve disorders, such as carpal tunnel
syndrome and peripheral neuropathy. The effects of glucocorticoids are mainly anti …