Failure to account for density variation during respiration can significantly affect PET quantitation in the lung.
B Holman, V Cuplov, L Millner, B Hutton, A Groves… - 2015 - Soc Nuclear Med
1770 Objectives PET quantitation in the lung is affected by local density changes due to
respiration and hence needs accurate attenuation maps (AM) for attenuation correction (AC) …
respiration and hence needs accurate attenuation maps (AM) for attenuation correction (AC) …
The effect of respiratory induced density variations on non-TOF PET quantitation in the lung
BF Holman, V Cuplov, BF Hutton… - Physics in Medicine …, 2016 - iopscience.iop.org
Accurate PET quantitation requires a matched attenuation map. Obtaining matched CT
attenuation maps in the thorax is difficult due to the respiratory cycle which causes both …
attenuation maps in the thorax is difficult due to the respiratory cycle which causes both …
Density variation during respiration affects PET quantitation in the lung
BF Holman, V Cuplov, O Bertolli… - 2015 IEEE Nuclear …, 2015 - ieeexplore.ieee.org
PET quantitation depends on the accuracy of the CT-derived attenuation correction map. In
the lung, respiration leads to both positional and density mismatches, causing PET …
the lung, respiration leads to both positional and density mismatches, causing PET …
The importance of correction for tissue fraction effects in lung PET: preliminary findings
Purpose It has recently been recognized that PET/CT may play a role in diffuse parenchymal
lung disease. However, interpretation can be confounded due to the variability in lung …
lung disease. However, interpretation can be confounded due to the variability in lung …
Improving pulmonary tissue fraction correction of pet images: Is correcting for collagen and blood required?
B Holman, D Butler, A Groves, B Hutton - 2013 - Soc Nuclear Med
2078 Objectives Correcting for tissue fraction effects (TFE) during PET/CT imaging increases
understanding of measured 18-FDG uptake within the lungs and reduces inter-subject …
understanding of measured 18-FDG uptake within the lungs and reduces inter-subject …
High-temporal-resolution lung kinetic modeling using total-body dynamic PET with time-delay and dispersion corrections
Tracer kinetic modeling in dynamic PET has the potential to improve the diagnosis,
prognosis, and research of lung diseases. The advent of total-body PET systems with much …
prognosis, and research of lung diseases. The advent of total-body PET systems with much …
Issues in quantification of registered respiratory gated PET/CT in the lung
V Cuplov, B Holman, B Hutton, A Groves, K Thielemans - 2015 - Soc Nuclear Med
537 Objectives Lung density changes during respiration which affects PET/CT quantification
in the lung. We investigate the relation between density changes measured in CT, FDG …
in the lung. We investigate the relation between density changes measured in CT, FDG …
Preliminary results from a novel phantom design for harmonisation of lung PET/CT studies.
F Leek, C Anderson, A Robinson, R Moss, B Hutton… - 2024 - Soc Nuclear Med
241445 Introduction: Current harmonisation efforts in PET/CT focus on oncology and brain
studies. However, there is a similar need for studies of diffuse lung disease [1], where voxel …
studies. However, there is a similar need for studies of diffuse lung disease [1], where voxel …
Respiratory gated PET based on time activity curve analysis
1741 Objectives: Respiratory motion in PET degrades images and limits detectability and
characterization of small or low-contrast lesions. Although image quality can in principle be …
characterization of small or low-contrast lesions. Although image quality can in principle be …
[HTML][HTML] Improved quantitation and reproducibility in multi-PET/CT lung studies by combining CT information
BF Holman, V Cuplov, L Millner, R Endozo, TM Maher… - EJNMMI physics, 2018 - Springer
Background Matched attenuation maps are vital for obtaining accurate and reproducible
kinetic and static parameter estimates from PET data. With increased interest in PET/CT …
kinetic and static parameter estimates from PET data. With increased interest in PET/CT …