[HTML][HTML] Muscone abrogates breast cancer progression through tumor angiogenic suppression via VEGF/PI3K/Akt/MAPK signaling pathways

D Wang, X Liu, W Hong, T Xiao, Y Xu, X Fang… - Cancer Cell …, 2024 - Springer
Background Angiogenesis strongly reflects poor breast cancer outcome and an important
contributor to breast cancer (BC) metastasis; therefore, anti-angiogenic intervention is a …

[HTML][HTML] A network-based pharmacological study on the mechanism of action of muscone in breast cancer

Y Zhao, S Tao, Q Wang, Y Liu, W Yang… - Translational Cancer …, 2022 - ncbi.nlm.nih.gov
Background The purpose of this study was to investigate the mechanism of action of
muscone on breast cancer using network pharmacology and molecular docking techniques …

[HTML][HTML] Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression

L Yang, S Yu, Y Yang, Y Zhao, F Wang, Y Chen… - Biomedicine & …, 2021 - Elsevier
Inhibition of tumor angiogenesis is a highly effective strategy for cancer treatment. Human
antigen R (HuR), an RNA-binding protein, is overexpressed in many cancers and regulates …

[HTML][HTML] Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor …

JH Kim, MS Kim, BH Lee, JK Kim… - Oncology …, 2017 - spandidos-publications.com
In the present study, we investigated the effects and molecular mechanism of marmesin, a
natural coumarin compound isolated from Broussonetia kazinoki, on non-small cell lung …

Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo

S Saraswati, SS Agrawal - Cancer Letters, 2013 - Elsevier
In this study, we investigated the mechanism of brucine in tumor angiogenesis. We found
that brucine inhibits VEGF-induced cell proliferation, chemotactic motility, and the formation …

Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis

S Sinha, S Khan, S Shukla, AD Lakra, S Kumar… - The international journal …, 2016 - Elsevier
Available breast cancer therapeutic strategies largely target the primary tumor but are
ineffective against tumor metastasis and angiogenesis. In our current study, we determined …

[HTML][HTML] Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth

YY He, S Liu, DS Newburg - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Colorectal cancer is the second deadly cancer in the world. Trametes versicolor is a
traditional Chinese medicinal mushroom with a long history of being used to regulate …

Muscone suppresses gastric cancer via regulation of miRNA‐145

F Gao, S Yan, Z Sun, J Wang - Food Science & Nutrition, 2021 - Wiley Online Library
This study aims to determine the effects and mechanism of action of muscone on the
biological activity of the gastric cancer cell lines SGC‐7901 and MGC‐803 (proliferation …

Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway

NH Kim, NJ Sung, S Shin, DS Ryu, HS Youn… - Bioscience …, 2021 - portlandpress.com
Sauchinone, a lignan isolated from Saururus chinenesis, is known to exhibit anti-
inflammatory and anti-oxidant effects. Recently, sauchinone has been reported to inhibit the …

Flavonoid extract Kushenol a exhibits anti‐proliferative activity in breast cancer cells via suppression of PI3K/AKT/mTOR pathway

T Liu, J Gong, G Lai, Y Yang, X Wu, X Wu - Cancer Medicine, 2023 - Wiley Online Library
Background Kushenol A is natural flavonoid extract discovered in recent years, with
potential anti‐tumor activity. Its role in breast cancer is poorly understood. Methods To …