Current treatments for diseases caused by apicomplexan and trypanosomatid parasites are
inadequate due to toxicity, the development of drug resistance and an inability to eliminate …

Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called
apicoplast that is the most reduced organelle of this type known. Due to the medical …

Human diseases like malaria, toxoplasmosis or cryptosporidiosis are caused by intracellular
protozoan parasites of the phylum Apicomplexa and are still a major health problem …

Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …

The apicoplast and mitochondrion of the malaria parasite Plasmodium falciparum are
important intracellular organelles and targets of several anti-malarial drugs. In recent years …

The malaria parasite harbors a relict plastid called the apicoplast and its discovery opened a
new avenue for drug discovery and development due to its unusual, nonmammalian …

Autophagy is a catabolic process widely conserved among eukaryotes that permits the rapid
degradation of unwanted proteins and organelles through the lysosomal pathway. This …

The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to
generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary …

The apicoplast is a recently discovered, plastid-like organelle present in most apicomplexa.
The methylerythritol phosphate (MEP) pathway involved in isoprenoid biosynthesis is one of …

The intracellular protozoan Toxoplasma gondii lacks a de novo mechanism for cholesterol
synthesis and therefore must scavenge this essential lipid from the host environment. In this …