Clostridium botulinum C2 toxin: binding studies with fluorescence-activated cytometry

BG Stiles, D Blöcker, ML Hale, MA Guetthoff, H Barth - Toxicon, 2002 - Elsevier
Clostridium botulinum C2 enterotoxin consists of two unlinked proteins designated as C2II,
which recognizes a cell-surface glycoprotein and translocates an ADP-ribosyltransferase …

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

H Barth, D Blöcker, J Behlke… - Journal of Biological …, 2000 - ASBMB
The actin-ADP-ribosylating binaryClostridium botulinum C2 toxin consists of two individual
proteins, the binding/translocation component C2II and the enzyme component C2I. To elicit …

The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

H Barth, R Roebling, M Fritz, K Aktories - Journal of Biological Chemistry, 2002 - ASBMB
The binary Clostridium botulinum C2 toxin is composed of the enzyme component C2I and
the binding component C2II, which are individual and non-linked proteins. Activated C2IIa …

The C Terminus of Component C2II ofClostridium botulinum C2 Toxin Is Essential for Receptor Binding

D Blöcker, H Barth, E Maier, R Benz… - Infection and …, 2000 - Am Soc Microbiol
The binary Clostridium botulinum C2 toxin consists of two separate proteins, the binding
component C2II (80.5 kDa) and the actin-ADP-ribosylating enzyme component C2I (49.4 …

Formation of a Biologically Active Toxin Complex of the Binary Clostridium botulinum C2 Toxin without Cell Membrane Interaction

E Kaiser, G Haug, M Hliscs, K Aktories, H Barth - Biochemistry, 2006 - ACS Publications
Clostridium botulinum produces a binary toxin, which is composed of two separate proteins.
The enzyme component, C2I, is an ADP-ribosyltransferase which modifies G-actin of …

Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

D Blöcker, K Pohlmann, G Haug, C Bachmeyer… - Journal of Biological …, 2003 - ASBMB
The binary Clostridium botulinum C2 toxin consists of two individual proteins, the transport
component C2II (80 kDa) and the enzyme component C2I, which ADP-ribosylates G-actin in …

Intracellular trafficking of Clostridium botulinum C2 toxin

M Nagahama, C Takahashi, K Aoyanagi, R Tashiro… - Toxicon, 2014 - Elsevier
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic component (C2I)
and binding component (C2II). The activated binding component (C2IIa) forms heptamers …

Binding and Internalization of Clostridium botulinum C2 Toxin

M Nagahama, T Hagiyama, T Kojima… - Infection and …, 2009 - Am Soc Microbiol
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic component (C2I)
and a binding component (C2II). The activated binding component (C2IIa) forms heptamers …

Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates

M Eckhardt, H Barth, D Blöcker, K Aktories - Journal of Biological …, 2000 - ASBMB
Clostridium botulinum C2 toxin is a binary toxin composed of an enzymatic subunit (C2I)
capable of ADP-ribosylating actin and a binding subunit (C2II) that is responsible for …

Functional Characterization of an Extended Binding Component of the Actin-ADP-Ribosylating C2 Toxin Detected in Clostridium botulinum Strain (C) 2300

C Sterthoff, AE Lang, C Schwan, A Tauch… - Infection and …, 2010 - Am Soc Microbiol
Clostridium botulinum C2 toxin consists of the binding component C2II and the enzyme
component C2I, which ADP-ribosylates G-actin of eukaryotic cells. Trypsin-activated C2II …