Free Radicals and Amiodarone Toxicity. Introduction: In vitro and in vivo studies were
performed to elucidate the pathogenesis of amiodarone toxicity. Methods and Results: Rats …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …

Background—Oxidative stress plays an important role in the pathophysiology of ischemic
heart disease and heart failure, and antioxidants might be beneficial in the treatment of …

Amiodarone is a potent antidysrhythmic drug that is associated with severe pulmonary
toxicity. The mechanism of amiodarone pulmonary toxicity is poorly understood. To …

The effectiveness of amiodarone in the treatment of cardiac arrhythmias is limited due to the
development of pulmonary toxicity. Although the biochemical and morphologic …

Hepatic enzymes, pulmonary function, serum amiodarone and desethylamiodarone (DEA)
concentrations and erythrocyte superoxide dismutase (SOD) activity were monitored at …

Amiodarone is a potent anti-arrhythmic drug used for the treatment of cardiac arrhythmias.
Although, the effects of amiodarone are well characterized on post-ischemic heart and …

Lipoprotein oxidation is crucial in atherogenic processes. Amiodarone is a lipophilic
antiarrhythmic/antianginal drug which is able to influence the physicochemical status of …